Metoprolol treatment of dual copyright and bupropion cardiovascular and central nervous system toxicity

Metoprolol treatment of dual copyright and bupropion cardiovascular and central nervous system toxicity

Blog Article

Cardiovascular and central nervous system (CNS) toxicity, including tachydysrhythmia, agitation, and seizures, may arise from copyright or bupropion use.We Tilt Sensor report acute toxicity from the concomitant use of copyright and bupropion in a 25-year-old female.She arrived agitated and uncooperative, with a history of possible antecedent copyright use.Her electrocardiogram demonstrated tachycardia at 130 beats/min, with a corrected QT interval of 579 ms.

Two doses of 5 mg intravenous metoprolol were administered, which resolved the agitation, tachydysrhythmia, and corrected QT interval prolongation.Her comprehensive toxicology screen returned positive for both copyright and bupropion.We believe clinicians should be aware of the potential for synergistic cardiovascular and CNS toxicity from concomitant copyright and bupropion 4 PC Table with Bench use.Metoprolol may represent an effective initial treatment.

Unlike benzodiazepines, metoprolol directly counters the pharmacologic effects of stimulants without respiratory depression, sedation, or paradoxical agitation.A lipophilic beta-blocker, metoprolol has good penetration of the CNS and can counter stimulant-induced agitation.